2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141380
    Bromoacetamido-PEG2-C2-acid 1415800-44-0 99.82%
    Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG2-C2-acid
  • HY-140457
    Azido-PEG24-acid 2195075-62-6 99.88%
    Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-acid
  • HY-138692
    Azido-PEG4-azide 182760-73-2
    Azido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-azide
  • HY-141387
    Bromoacetamido-PEG4-NHS ester 1260139-70-5 98.69%
    Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG4-NHS ester
  • HY-140341A
    Sulfo-NHS-Acetate sodium 221222-61-3
    Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker. Sulfo-NHS-Acetate sodium can be used in the synthesis of PROTACs.
    Sulfo-NHS-Acetate sodium
  • HY-140233
    Boc-amido-PEG9-amine 890091-43-7 ≥98.0%
    Boc-amido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-amido-PEG9-amine
  • HY-140342
    Boc-C16-NHS ester 843666-34-2 98.0%
    Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C16-NHS ester
  • HY-130435
    DBCO-PEG4-amine 1840886-10-3
    DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker). DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-amine
  • HY-140699
    m-PEG-NHS ester (MW 10000) 92451-01-9 98.0%
    m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-NHS ester (MW 10000)
  • HY-126881
    Fmoc-PEG2-C2-NHS ester 1807534-85-5 98.89%
    Fmoc-PEG2-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG2-C2-NHS ester
  • HY-133143
    1,2-Bis(2-iodoethoxy)ethane 36839-55-1 98.66%
    1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively.
    1,2-Bis(2-iodoethoxy)ethane
  • HY-W004868
    1-Cbz-azetidine-3-carboxylic acid 97628-92-7 99.58%
    1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
    1-Cbz-azetidine-3-carboxylic acid
  • HY-130379
    Propargyl-PEG8-acid 2055014-94-1 98.0%
    Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-acid
  • HY-W016429
    H-cis-Hyp-OMe hydrochloride 40126-30-5 98.0%
    H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
    H-cis-Hyp-OMe hydrochloride
  • HY-79125
    Fmoc-Hyp(Bom)-OH 187223-15-0 98.0%
    Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
    Fmoc-Hyp(Bom)-OH
  • HY-130145
    m-PEG8-CH2COOH 102013-72-9 99.88%
    m-PEG8-CH2COOH is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG8-CH2COOH
  • HY-141234
    HO-PEG13-OH 17598-96-8 ≥98.0%
    HO-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG13-OH
  • HY-132004
    Tos-O-C4-NH-Boc 180851-50-7
    Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250).
    Tos-O-C4-NH-Boc
  • HY-140249
    Tri(Amino-PEG3-amide)-amine 2523025-40-1 98.0%
    Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tri(Amino-PEG3-amide)-amine
  • HY-140266
    DBCO-PEG2-acid 2304558-25-4
    DBCO-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG2-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG2-acid
PROTAC Linkers Isoform Comparison

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